Contraindications, Interactions, and Side Effects (Pareira) : Not covered (AHP). “Hazards and/or side effects not known for proper therapeutic dosages” (not given) (PH2). Overdoses of tubocurarine (and other curare alkaloids) can cause respiratory paralysis and hypotension. LD50’s are less than 1 mg/kg, 0.56 subcutaneously in mice, 0.5 intraperitoneally, and 0.18 intravenously in mice, and 0.2 mg/kg ivn in rabbits. An injection of neostigmine methylsulfate is suggested as an antidote (HAD).
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