Contraindications, Interactions, and Side Effects (Stevia) : Class 1 (AHP). No health hazards known with proper use as a sweetener (PH2). AMA (Alternative Medicine Alert) suggests that one byproduct of stevia metabolism may be mutagenic (APA); steviol, a metabolite of stevioside “has been found to be highly mutagenic in several in vitro studies” (AMA 3:13). Insufficient human data exist regarding safety in pregnancy and lactation. Hence, “pregnant and lactating patients should avoid stevia” (AMA 3:13). Limited data suggest it may be a contraceptive (APA). Stevioside is “about one hundred times sweeter than sucrose at a 10% concentration” (APA). Liquid leaf extracts significantly decrease plasma glucose levels after overnight fasting in 16 healthy adults (APA).
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