SOUTHERN PRICKLY ASH

SOUTHERN PRICKLY ASH (Zanthoxylum clava-herculis L.) +

Activities (Southern Prickly Ash) :
Analgesic (f; CAN; PNC); Antihelicobacter (1; X9781854); Antiinflammatory (f; CAN; PNC); Antirheumatic (f; CAN; PNC); Antiseptic (1; PNC); Antispasmodic (f; HHB); Antiulcer (1; X9781854); Carminative (f; CAN; HHB; PNC); Circulostimulant (f; CAN; PNC); Diaphoretic (f; CAN; HHB; HH3; PNC); Diuretic (f; HHB); Hypotensive (f; CAN); Larvicide (f; HH3); Sedative (f; CAN); Sialagogue (f; CAN); Stomachic (f; HHB); Tonic (f; HHB).

Indications (Southern Prickly Ash) :
Cramp (f; HHB); Diarrhea (f; PNC); Fever (f; CAN; HHB; HH3; PNC); Helicobacter (1; X9781854); High Blood Pressure (f; CAN); Infection (f; PNC); Inflammation (f; CAN; PNC); Insomnia (f; CAN); Intermittent Claudication (f; HH3); Nervousness (f; CAN); Pain (f; PNC; CAN); Raynauds Syndrome (f; HH3); Rheumatism (f; CAN; HH3; PNC); Swelling (f; DEM); Toothache (f; DEM; HHB; PNC); Ulcer (1; X9781854).

Dosages (Southern Prickly Ash) :
5 g bark/750 ml water up to 3 ×/day (APA); 1 - 3 g dry bark, or in tea, 3 ×/day (CAN; HH3); 1 - 3 ml liquid bark extract (PNC); 1 - 3 ml liquid bark extract (1:1 in 45% ethanol) 3 ×/day (CAN); 2 - 5 ml bark tincture (1:5 in 45% ethanol) 3 ×/day (CAN); 0.5 - 1.5 g dry berries (CAN); 0.5 - 1.5 ml liquid berry extract (1:1 in 45% ethanol) (CAN); 0.5 - 1.5 ml liquid fruit extract (PNC).

Contraindications, Interactions, and Side Effects (Southern Prickly Ash) :
Class 2b (AHP). Reported to be toxic to animals (lethal to cattle, chicken, and fish). Because of pharmacologically active alkaloids and coumarins, its use in pregnancy and lactation is to be avoided. May interfere with anticoagulant therapy. Excessive use should be avoided (CAN).

Extracts (Southern Prickly Ash) :
Bark extracts act as a reversible neuromuscular blocking agent. A single hypotensive dose of nitidine chloride (2 mg/kg) lowered blood pressure 20% in mice within 90 minutes, persisting for 6 hours. Nitidine also antagonizes the hypertensive effects of angiotensin. Nitidine is antileukemic. Chelerythrine, at 10 mg/kg (orl rat), was comparable in antiinflammatory activity to indomethacin at 5 mg/kg. Chelerythrine also works against Candida and Gram-positive if not Gram-negative bacteria. Chelerythrine potentiates the analgesia of morphine, prolongs barbiturate sleep, and is hypotensive following an immediate hypertensive thrust (cats, mice, rats). Asirinin has antitubercular activity; neoherculin is insecticidal, piscicidal, and sialagogue.