Dosages (Soapwort) : 1.5 g root/day (KOM); 1 tsp root in cold tea (MAD); 0.4–1.5 g (1/8 to 1/3 tsp) bark/day (APA); 0.4 g/cup bark tea (PHR); 2–4 fl oz bark extract (FEL); 1–2 g bark extract (MAD).
Contraindications, Interactions, and Side Effects (Soapwort) : Not covered (AHP). Rare stomach irritation (KOM). Large doses may be poisonous (FAD). Saponins are hemolytic (FAD; FNF). May irritate mucus membranes and skin (PHR). May induce emesis and diarrhea (APA). Patients with GI problems and ulcers should possibly avoid (APA). A ribosome-activating protein (RIP), called saporin 6, inhibits the growth of breast cancer cells in vitro (Wagner et al., 1995). Quillaiac acid contributes to diuretic activity (FNF).
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