PRICKLY ASH ZANTHOXYLUM SPP

PRICKLY ASH (Zanthoxylum spp.) +

Synonyms :
Zanthoxylum americanum Mill. in FEL, Z. fraxineum in MAD.

Activities (Prickly Ash) :
Abortifacient (f; DEM); Alterative (f; FEL); Analgesic (1; APA); Anesthetic (1; APA); Antihelicobacter (1; X9781854); Antiinflammatory (1; APA; PHR); Antiperistaltic (1; FNF); Antirheumatic (f; APA; CAN; PHR); Antispasmodic (f; HHB; PH2); Antiulcer (1; X9781854); Candidicide (1; FNF); Carminative (f; CAN; FEL; HHB); Choleretic (f; FAD); Circulostimulant (f; CAN); Cytotoxic (f; HH3); Diaphoretic (f; CAN; FEL; MAD; PHR); Diuretic (f; DEM; FAD; FEL; MAD); Emmenagogue (f; FEL; MAD); Expectorant (f; DEM); Hypotensive (1; APA); Nephrotonic (f; FEL); Nervine (f; HH3); Pancreatonic (f; FAD; FEL); Secretagogue (1; FEL); Sialagogue (1; APA; CAN; FAD; FEL; HH3); Stimulant (1; APA); Stomachic (f; HHB); Tonic (f; HHB); Vulnerary (f; HH3).

Indications (Prickly Ash) :
Amenorrhea (f; MAD); Anemia (1; JAD; FNF); Arthrosis (f; DEM); Asthma (f; PH2); Ataxia (f; FEL); Atherosclerosis (f; MAD); Backache (f; DEM); Bleeding (f; DEM); Bronchosis (f; DEM); Burn (f; DEM); Cancer (1; FAD; HH3; HOX; JAD); Candida (1; FNF); Cardiopathy (f; DEM; FAD); Catarrh (f; FEL); Cholera (f; FEL); Coccus (f; MAD); Cold (f; DEM; FAD; HH3); Colic (f; FEL; HH3; PH2); Constipation (f; FEL); Convulsion (f; DEM); Cough (f; DEM; FAD; PH2); Cramp (f; CAN; HHB; MAD; PH2); Diarrhea (f; PH2); Dropsy (f; FEL); Dysentery (f; FAD); Dysmenorrhea (f; FEL; MAD); Dyspepsia (f; FAD; FEL; PH2); Earache (F; HH3); Enterosis (f; FEL); Fever (f; CAN; DEM; FEL; MAD; PHR; PH2); Gas (f; FEL; PH2); Gastrosis (f; FEL); Gonorrhea (f; DEM; HH3); Headache (f; PH2); Helicobacter (1; X9781854); Hemiplegia (f; FEL; MAD); High Blood Pressure (1; APA); Hip Ache (f; MAD); Hypotension (f; PHR; PH2); Hysteria (f; HH3; MAD); Impaired Peripheral Circulation (f; CAN); Inflammation (1; APA; PHR; PH2); Intermittent Claudication (f; CAN); Ischiosis (f; HH3; MAD); Itch (f; DEM); Leprosy (f; PH2); Leukorrhea (f; MAD); Lumbago (f; FEL; MAD); Malaria (f; FEL); Mucososis (f; FEL); Myalgia (f; FEL); Nephrosis (f; DEM; FAD); Neuralgia (f; FEL; MAD); Neurosis (f; FAD; HH3; MAD); Ophthalmia (f; PH2); Otosis (f; HH3; PH2); Ovariosis (f; MAD); Pain (1; APA; DEM); Pancreatosis (f; FAD); Paralysis (f; FEL; PH2); Pharyngosis (f; FEL); Pulmonosis (f; DEM; FAD); Raynaud’s Syndrome (f; CAN); Rheumatism (f; APA; CAN; DEM; FAD; FEL; MAD; PHR; PH2); Scrofula (f; FEL); Sickle Cell (1; JAD; FNF); Sore (f; FEL); Sore Throat (f; DEM; FAD; FEL; HH3); Stomatosis (f; FEL); Syphilis (f; FEL; HH3; MAD); Tonsilosis (f; DEM; FAD); Toothache (1; DEM; FAD; FEL; FNF; JAD; MAD; PH2); Torticollis (f; FEL); Tuberculosis (f; DEM); Typhoid (f; FEL); Ulcer (1; X9781854); VD (f; DEM; FEL); Vomiting (f; DEM); Worm (f; DEM; PH2); Yeast (1; FNF).

Dosages (Prickly Ash) :
1–3 g dry bark, or in tea, 3 ×/day (APA; CAN); 0.6–1.8 g powdered bark (MAD); 1–3 ml liquid bark extract (PNC); 1–3 ml liquid bark extract (1:1 in 45% ethanol) 3 ×/day (APA; CAN); 2–5 ml bark tincture (1:5 in 45% ethanol) 3 ×/day (CAN); 0.5–1.5 g dry berries (CAN); 0.5–1.5 ml liquid berry extract (1:1 in 45% ethanol) (APA; CAN); 0.5–1.5 ml liquid fruit extract (PNC).

Contraindications, Interactions, and Side Effects (Prickly Ash) :
Class 2b (AHP). None reported (PHR). Reported to be toxic to animals (CAN). Because of pharmacologically active alkaloids and coumarins, its use in pregnancy and lactation is to be avoided. May interfere with anticoagulant therapy. Excessive use should be avoided (CAN).

Extracts (Prickly Ash) :
Bark extracts act as a reversible neuromuscular blocking agent. A single hypotensive dose of nitidine chloride (2 mg/kg) lowered blood pressure 20% in mice within 90 minutes, persisting for 6 hours. Nitidine also antagonizes the hypertensive effects of angiotensin. Chelerythrine, at 10 mg/kg (orl rat), was comparable in antiinflammatory activity to indomethacin at 5 mg/kg. Chelerythrine also works against Candida and Gram-positive, if not Gram-negative, bacteria. Chelerythrine potentiates the analgesia of morphine, prolongs barbiturate sleep, and is hypotensive following an immediate hypertensive thrust (in cats, mice, and rats). Asirinin has antitubercular activity; neoherculin is insecticidal and sialagogue.