OREGON GRAPE MAHONIA AQUIFOLIUM

OREGON GRAPE (Mahonia aquifolium (Pursh) Nutt.) +

Synonyms :
Berberis aquifolium Pursh, B. diversifolia (Sweet) Steud., Mahonia diversifolia Sweet.

Activities (Oregon Grape) :
Alterative (f; CRC; FEL; HHB; MAD); Amebicide (1; CRC); Anaphrodisiac (f; CRC); Antialzheimeran (1; COX; FNF); Antiarthritic (1; COX; FNF); Antibacterial (1; DEM; FNF; WAM); Antibilious (f; CRC); Anticancer (1; COX; FNF); Anticonvulsant (1; CRC); Antihelicobacter (1; X9781854); Antiinflammatory (1; COX; FNF); Antioxidant (1; APA); Antiperistaltic (1; FNF); Antiprolific (1; PHR); Antipsoriatic (1; PHR; PH2); Antipyretic (f; CRC); Antiseptic (1; DEM; CRC; FNF); Antitrypanosomic (1; CRC); Antiulcer (1; X9781854); Aquaretic (f; SHT); Bitter (1; PH2); Carminative (f; CRC); Cholagogue (f; CRC); Choleretic (1; CRC); Collyrium (1; DEM; FNF); COX-2 Inhibitor (1; COX; FNF); Depurative (f; APA; CRC; DEM); Digestive (1; WAM); Diuretic (f; APA; CRC); Expectorant (f; CRC); Fungicide (1; APA); Hepatotonic (1; WAM); Hypotensive (1; CRC); Laxative (f; CRC); MDR Inhibitor (1; FNF; JAD); Mutagenic (1; PH2); Orexigenic (f; CRC; PH2); Parasiticide (1; WAM); Sedative (1; CRC); Tonic (f; APA; CRC; DEM; FEL; PH2); Uterotonic (1; CRC).

Indications (Oregon Grape) :
Acne (f; APA; MAD); Alzheimer’s (1; COX; FNF); Ameba (1; CRC); Anemia (f; FEL); Anorexia (1; CRC); Arthrosis (1; COX; DEM; FNF); Bacteria (1; CRC; DEM; FNF; WAM); Bleeding (1; DEM; FNF); Bronchosis (f; CRC; FEL; PH2); Bronchorrhea (f; FEL); Bruise (f; APA); Burn (f; HHB); Cachexia (f; FEL); Cancer (1; COX; FNF); Catarrh (f; FEL); Cholecystosis (f; CRC; MAD; PH2); Cirrhosis (f; FEL); Cold (1; WAM); Congestion (f; CRC); Constipation (f; APA; CRC; FEL); Convulsion (1; CRC); Cough (1; APA; WAM); Dandruff (1; PHR); Dermatosis (1; APA; FEL; MAD; PHR; PH2); Diarrhea (f; CRC; HHB; MAD); Dyscrasia (f; FEL); Dysentery (f; MAD); Dyspepsia (1; CRC; DEM; FNF; HHB; PH2); Dysuria (f; CRC; MAD); Eczema (1; APA; CRC; FEL; PH2; WAM); Enterosis (1; FEL; MAD; WAM); Erysipelas (f; FEL); Fever (f; CRC; MAD); Fungus (1; APA); Gallstone (f; CRC; HHB); Gastrosis (f; FEL; PH2); Gout (f; CRC; MAD); Gravel (f; CRC); Helicobacter (1; X9781854); Hepatosis (1; APA; CRC; PH2); Herpes (f; CRC; FEL; MAD); High Blood Pressure (1; CRC); Infection (1; APA; CRC; WAM); Inflammation (1; COX; FNF); Insomnia (1; CRC); Jaundice (f; APA); Kidney Stone (f; MAD); Leukorrhea (f; CRC); Leishmaniasis (1; CRC; FNF); Malaria (1; CRC); Myalgia (f; FEL); Mycosis (1; APA); Nephrosis (f; APA; DEM); Nervousness (1; CRC); Neuralgia (f; MAD); Ophthalmia (1; DEM; FNF); Pain (f; FEL; MAD); Parasite (1; WAM); Periosteosis (f; FEL); Phthisis (f; FEL); Pityriasis (f; FEL); Psoriasis (1; APA; CRC; FEL; HHB; MAD; PHR; PH2); Pulmonosis (1; WAM); Rash (f; PH2); Rheumatism (1; CRC; COX; MAD); Rhinosis (1; WAM); Scrofula (f; FEL); Sinusosis (1; WAM); Sore (f; FEL; HHB); Sore Throat (1; DEM; FNF); Stomatosis (f; FEL); Stone (f; SHT); Syphilis (1; CRC; DEM; FEL; FNF; MAD); Trachoma (f; CRC); Tuberculosis (1; DEM; FEL; FNF); Typhoid (f; MAD); Ulcer (1; APA; X9781854); Uterosis (f; CRC); UTI (SHT); Vaginosis (1; CRC); VD (1; CRC; FEL; MAD); Yellow Fever (1; DEM; FNF); Wound (f; APA).

Dosages (Oregon Grape) :
0.5 tsp root bark/cup water 1 ×/day (APA); 2 g root bark (HHB); 1–2 ml liquid root extract (APA; PNC); 10–20 drops fluid extract/3–4 hours (FEL); 0.3–1.5 g fluid extract (MAD); 0.6–3.75 g tincture (MAD).

Contraindications, Interactions, and Side Effects (Oregon Grape) :
Class 2b. Canada requires bilingual warning against use during pregnancy (AHP). “Not allowed as a non-medicinal ingredient in oral use products in Canada” (Michols, 1995). “Hazards and/or side effects not known for proper therapeutic dosages” (PH2). If Barney is right in saying that “goldenseal should not be taken for long periods of time,” I suspect that the same would be true for those herbs containing similar compounds, such as barberry, goldthread, oregon grape, and yellow root (Barney, 1996). Therefore, I have lowered their safety ratings to one +. “Large doses of berberine can cause fatal poisoning” (CRC). White and Mavor preclude use in children under 1 year old, or during pregnancy (WAM). An alternative source of the COX-2 inhibitor, berberine (COX; FNF). Recently shown to contain a pump-efflux inhibitor, 5'-methoxyhydnocarpin (5'-MHC) synergistic with antiseptic alkaloids.