Dosages (Malabar Nut) : 1–20 grains for asthma and bronchosis (DEP); 1–2 g powdered leaf; 2 g powdered leaf (KAP); 8–16 ml leaf juice (KAP); 10–30 g powdered root bark (KAP); 28–56 ml bark decoction (KAP); 0.5–1.5 g dry herb/day or 1–3 ml day fluid extract (1:2) (KEB); 2–4 ml tincture; 1–2 ml liquid 1:1 extract (PH2; PNC).
Contraindications, Interactions, and Side Effects (Malabar Nut) : Not covered (AHP).“Hazards and/or side effects not known for proper therapeutic dosages” (PH2). Contraindicated in pregnancy except in assisting delivery (KEB). Potency of vasicine may be accentuated with piperine.
Extracts (Malabar Nut): Leaves contain the quinazoline alkaloids deoxyvasicine, vasicine, and vasicinone; the latter two are respiratory stimulants. At high doses vasicine protects against histamine-induced bronchospasm in guinea pigs. Its autooxidation product, vasicinone, had bronchodilatory activity in vitro and in vivo, and relaxes the tracheal muscle in vitro. Vasicinone is more potent than vasicine with antiasthmatic properties comparable to (NOTE: hype literature often uses the word comparable to mean can be compared to, not necessarily meaning equal to) disodium cromoglycate. Vasicinone is reportedly synergetic with vasicine on bronchodilation and ciliary movements. Their 1:1 mix is more bronchodilatory and antagonized histamine-induced bronchoconstriction than vasicine alone or theophylline. The cardiodepressant effect activity of vasicine was normalized by vasicinone. Flowers contain the antiasthmatic quercetin.
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