INDIAN IPECAC TYLOPHORA INDICA

INDIAN IPECAC (Tylophora indica (Burm. f.) Merr.) X

Synonym:
- Asclepias asthmatica L. f., Cynanchum indicum Burm. f., Tylophora asthmatica (L. f.) Wight & Arn.

Activities (Indian Ipecac) :
- Adrenergic (1; SAB); Adrenocorticotropic (1; SAB); Analgesic (f; SKJ); Antiallergic (2; KEB); Antianaphylactic (1; SAB); Antiasthmatic (2; KEB; SAB); Antiedemic (1; SAB); Antihistaminic (1; WOI); Antiinflammatory (1; KEB; SAB); Antileukemic (1; WOI); Antispasmodic (1; SAB); Antitumor (1; KEB); Bacteristat (1; WOI); CNS-Depressant (1; KEB); Diaphoretic (f; SKJ); Emetic (1; KEB); Expectorant (f; SKJ); Immunodepressant (1; KEB; SAB); Laxative (1; SKJ); Myocardiodepressant (1; WOI); Myorelaxant (1; SAB); Protisticide (1; KEB); Vermicide (f; WOI).

Indications (Indian Ipecac) :
- Allergy (2; KEB); Anaphylaxis (1; SAB); Asthma (2; KEB; SAB); Autoimmune Disease (2; KEB); Bronchosis (2; KEB; SAB); Cancer (1; KEB); Constipation (1; SKJ); Cramp (1; SAB); Diarrhea (f; WOI); Dysentery (2; KEB); Eosinophilia (1; KEB; SAB); Fever (f; SKJ); Gout (f; WOI); Hay Fever (2; KEB); Inflammation (2; KEB; SAB); Leukemia (1; WOI); Pain (f; SKJ); Pertussis (f; WOI); Rheumatism (f; SKJ); Rhinosis (2; KEB; SAB); Swelling (1; SAB); Tumor (1; KEB); Worm (f; WOI).

Dosages (Indian Ipecac) :
- 200 - 400 mg dry herb or 1 - 2 ml/day 1:5 tincture, for no more than 4 weeks; 2 (100 mg) capsules powdered leaf/day/6 day (SAB).

Contraindications, Interactions, and Side Effects (Indian Ipecac) :
- Not covered (AHP; KOM). Fresh leaves may cause nausea and vomiting (KEB). Alkaloids irritate the skin and are emetic (KEB). Dried leaves may cause fatal poisoning (WOI). Sore mouth, loss of taste, and/or vomiting, etc. occurred in 75% of patients after only 3 - 6 leaves. LD50 of the crude alcoholic extract of the drug was found to be 2 mg/kg (WOI). If correct this a very dangerous drug. That means less than
a gram (200 mg) of the tincture could kill me. Until I have better information, I have given the herb the X for safety.

Extracts (Indian Ipecac) :
- Extracts stimulate adrenal cortex, antagonize steroid-induced suppression of adrenal activity, and increase plasma steroid levels (KEB). Tylophorine is quite toxic (LD50 = 35 mg/kg orl rat) (KEB). Extracts ipr in mice (400 mg/kg) about as good an antiedemic as phenylbutazone (80 mg/kg). henanthroindolizidine alkaloids contribute to antiasthmatic activity. Sabinsa (1998) cites data comparing 10 mg/day of the bronchodilator isoprenaline sublingually with 2 capsules/day (100 mg) dry leaf. The herb was a bit better at improving lung function (SAB).