HOPS HUMULUS LUPULUS

HOPS (Humulus lupulus L.) +++

Activities (Hops) :
- Allergenic (f; CRC); Analgesic (1; BGB; CRC; MAD; PNC; WAM); Anaphrodisiac (1; APA; CRC; MAD); Antibacterial (1; APA; CAN; WAM); Antiseptic (1; CRC; FAD); Antispasmodic (1; APA; BGB; WAM); Antitumor (1; APA); Aperitif (1; PH2; SKY); Bitter (1; CRC; PNC); Diaphoretic (f; CRC); Digestive (1; APA; WAM); Diuretic (f; CRC; PNC); Emmenagogue (f; MAD); Emollient (f; APA); Estrogenic (1; APA; FNF; PH2; WAM); Expectorant (f; PED); Fungicide (1; APA; PH2); Hypnotic (1; CAN; CRC); Lactagogue (1; WAM); Laxative (f; MAD); Litholytic (f; MAD); Myorelaxant (1; APA; CAN); Narcotic (1; CAN; CRC); Nervine (f; CRC); Secretagogue (f; PH2); Sedative (2; APA; KOM; WAM); Soporific (1; BGB; CRC); Stomachic (f; CRC; PH2); Tonic (f; CRC; MAD); Tranquilizer (1; KOM; SHT); Uterotonic (f; MAD);
Vermifuge (f; CRC).

Indications (Hops) :
- Adenopathy (f; JLH); Anemia (f; MAD); Angina (f; MAD); Anorexia (1; APA; BGB; SKY); Anxiety (2; APA; BGB; WAF; SHT); Arthrosis (f; MAD); Asbestosis (2; BGB); Asthma (f; MAD); Atony (f; MAD); Bacteria (1; APA; CAN; CRC; WAM); Boil (f; CRC; FAD); Bruise (f; CRC; FAD; MAD); Calculus (f; CRC); Cancer (1; APA; JLH); Cancer, breast (f; JLH); Cancer, face (f; JLH); Cancer, liver (f; JLH); Cancer, lymph (f; JLH); Cancer, spleen (f; JLH); Cancer, stomach (f; JLH); Cancer, uterus (f; CRC); Cardiopathy (f; MAD); Catarrh (f; MAD); Chlorosis (f; MAD); Climacteric (1; HHB); Colitis (f; CAN); Constipation (f; MAD); Cough (f; CRC; FAD); Cramp (1; APA; BGB; FAD; WAM); Crural Ulcer (f; CAN); Cystosis (f; APA; CRC; MAD); Debility (f; CRC); Delirium (f; CRC); Depression (f; CAN); Dermatosis (f; PH2); Diabetes (f; MAD); Diarrhea (1; APA; CRC); Dysentery (2; BGB; CRC); Dysmenorrhea (f; APA); Dyspepsia (1; APA; BGB; WAM); Earache (f; CRC); Edema (f; MAD); Enterosis (f; MAD; PH2); Enuresis (f; MAD); Fever (f; CRC; FAD); Fit (f; CRC); Fungus (1; APA; PH2); Gas (f; MAD); Gastrosis (f; JLH); Gonorrhea (f; MAD); Gravel (f; BGB); Headache (1; BGB; PH2; WAM); Hepatosis (f; JLH; MAD); Hyperactivity (1; WAM); Hypochondria (f; MAD); Hysteria (f; CRC; MAD); Impotence (f; MAD); Induration (f; JLH); Infection (1; APA; CRC; PH2); Inflammation (f; CRC; FAD; PH2); Insomnia (2; APA; CRC; KOM; SHT; WAM); Jaundice (f; CRC; MAD); Leprosy (2; APA; BGB; CRC); Mastosis (f; BGB; JLH); Menopause (f; HHB); Morning Sickness (f; MAD); Mucososis (f; PH2); Mycosis (1; APA; PH2); Nephrosis (f; BGB); Nerve (f; CRC); Nervousness (2; APA; KOM; PHR; PH2; SHT; WAM); Neuralgia (1; CAN; CRC); Neurasthenia (f; MAD);
Neurosis (f; APA); Nymphomania (f; MAD); Oligolactea (1; WAM); Onanism (f; MAD); Pain (1; BGB; CRC; MAD; PNC; WAM); Priapism (f; CAN; PH2); Prostatosis (f; MAD); Pulmonosis (f; CRC); Restlessness (2; KOM; SHT; WAM) (with tension headache and/or dyspepsia) (1; CAN); Rheumatism (f; BGB; CRC; FAD; MAD); Satyriasis (f; MAD); Scirrhus (f; JLH); Scrofula (f; MAD); Silicosis (2; BGB); Sore (f; JLH; PH2); Splenosis (f; JLH; MAD); Spermatorrhea (f; MAD); Stomachache (f; MAD); Stone (f; MAD); Stress (1; APA); Swelling (f; JLH); Toothache (f; CRC); Tuberculosis (1; APA; BGB; CRC); Tumor (1; APA; CRC);
Ulcer (f; CRC); Ulcus cruris (f; PH2); Uterosis (f; BGB); VD (f; MAD); Water Retention (f; CRC; MAD; PNC); Worm (f; CRC).

Dosages (Hops) :
- 500 mg/day (SF); 2 - 6 tsp fresh flower (PED); 1 - 3 g dry flower (PED); 2 g dry flower:10 ml alcohol/10 ml water (PED); 1 - 2 tsp inflorescence/cup water (SKY; WIC); 0.5 - 1 ( - 2 as hypnotic) g hops, or in tea (CAN; SKY); 0.5 - 1 g powdered herb; 0.5 - 15 g cones (PNC); 1 tsp (0.4 g) cone cup (PH2); 0.5 - 2.0 ml liquid hops extract (1:1 in 45% ethanol) (CAN); 0.5 - 4 ml liquid inflorescence extract (PNC); 1 - 2 ml hops tincture (1:5 in 60% ethanol) 1 - 3 ×/day (CAN; SKY); 2 - 4 ml inflorescence tincture (PNC); 2 - 4 g inflorescence tincture (MAD); 120 - 300 mg lupulin (PNC). Cones = flowers = dry infloresences.

Contraindications, Interactions, and Side Effects (Hops) :
- Class 2d (AHP). Hazards and/or side effects not known for proper therapeutic dosages (PH2). None reported (KOM; PHR; PIP). Some caution against use in depression (AHP). Mild allergies or dermatosis may result from contact. Oleo-resin reported to be allergenic, possibly causes dermatosis (CAN). Respiratory allergy caused by handling of hop cones (fresh hops oil, humulone, lupulone, and myrcene
produce positive skin patch tests). Pollen can cause contact dermatosis. They suggest that hops be contraindicated in depressive states as the sedative effect of hops may aggravate or accentuate symptoms. The sedative effect may potentiate the effects of existing sedative therapy and alcohol (CAN). In vitro antispasmodic activity on the uterus has been documented. Because of uterine activity, its use in pregnancy and lactation is to be avoided. Excessive use should be avoided in view of the limited toxicity data (CAN). Avoid if pregnant (WAM). Do not use if suffering estrogen-dependent disorders (WAM).

Extracts (Hops) :
- The LD50 for orally administered hop extract or lupulones in mice is ~500 - 3500 mg/kg (roughly 1/2 to 20th as toxic as caffeine). Ethanol extract antispasmodic and myorelaxant. Antibacterial activity has been documented for hops, humulone, and lupulone against Gram positive bacteria. The bitter acids exhibit antifungal activity against Candida, Fusarium, Mucor, and Trichophyton. The flavanones are antistaphylococcic and antifungal (Mucor and Trichophyton). Hops sedative and hypnotic, and motility-depressant properties are attributed to 2-methyl-3-buten-2-ol. Isovaleric acid may contribute to the sedativity. Hops reportedly contain several sedative, analgesic, anesthetic, and anodyne compounds as well. Piperidine, quercitrin, and ursolic acid may depress the CNS. Hops improve human sleep performance in combination with valerian and the hops are apparently effective in baths (Id suggest in combination with dilute lavender and lemonbalm). With uva ursi and alpha-tocopherol acetate, hops
gave excellent results for 772 of 915 patients with irritable bladder and urinary incontinence. Combined with the Biblical chicory and peppermint, hops documentably relieves pain in chronic cholecystosis (calculous and noncalculous).