GUGUL COMMIPHORA WIGHTII

GUGUL (Commiphora wightii (Arn.) Bhandari) ++

Synonyms :
- Balsamodendrum mukul Hook. ex Stocks, B. wightii Arn., C. mukul (Hook. ex Stocks) Engl.
I have seen gugul spelled guggul and treated under the scientific names Commiphora molmol, C.
mukul (synonym of C. wightii), and C. wightii, as I call it here. I doubt that there are many people
who can swear on a stack of Bibles whether a resin is one or the other species or a mixture of
many species. Let the buyer beware.

Activities (Gugul) :
- Alterative (f; DEP; KAB; KAP; MBB); Analgesic (1; JBU); Antiaging (f; AKT); Antiaggregant (1; KAP; KEB; PNC; SKY); Antiarthritic (1; MPI); Antiatherosclerotic (1; APA; KEB; MPI); Antiedemic (1; APA; KEB; MPI); Antiinflammatory (1; APA; KAP; KEB; PNC); Antiobesity (1; KEB); Antioxidant (1; KEB); Antiseptic (f; DEP; KAP; WOI); Antispasmodic (1; KAP; PNC); Antisuppurative (f; DEM; MPI); Antithrombic (1; KEB); Aperitif (f; DEP; KAB; KAP); Aphrodisiac (f; DEP; KAB; KAP); Astringent (f; KAP; WOI); Bitter (f; KAB; MBB); Cardioprotective (1; KEB); Carminative (f; DEP; KAB; KAP); Demulcent (f; DEP; KAB; KAP); Diaphoretic (f; MPI; WOI); Digestive (f; WOI); Diuretic (f; WOI); Ecbolic (f; MPI); Emmenagogue (f; KAP); Expectorant (f; DEP; KAB; WOI); Fibrinolytic (1; KEB); Hypocholesterolemic (1; PNC; SKY); Hypoglycemic (1; MPI); Hypolipidemic (1; PNC); Hypotriglyceridemic (1; KEB; SKY); Immunostimulant (1; WOI); Leucocytogenic (1; WOI); Lipolytic (1; AKT; APA; MBB; PNC; SKY); Mucolytic (f; AKT); Phagocytotic (1; WOI); Thyrotropic (1; AKT; APA; PNC); Uterotonic (f; WOI); Vermifuge (f; KAB).

Indications (Gugul) :
- Abscess (f; KAB); Acne (1; AKT; KEB); Adenopathy (f; AKT; KAB; MBB); Amenorrhea (f; KAP); Anemia (f; DEP); Angina (1; AKT); Anorexia (f; DEP; KAB; KAP); Arthrosis (1; AKT; APA; KAP; KEB; MBB; MPI); Ascites (f; KAB); Asthma (f; KAB); Atherosclerosis (1; APA; KEB; MPI; SKY); Atony (f; WOI); Bite (f; KAB); Bronchosis (f; BGB; WOI); Cancer (f; AKT; KAB; MBB); Cardiopathy (1; AKT; APA; KEB); Catarrh (f; WOI); Cramp (1; KAP; PNC); Cyst (f; AKT; MBB); Dermatosis (f; DEP; KAB); Diabetes (1; MPI); Dysmenorrhea (f; KAP); Dyspepsia (f; DEP; KAB); Dyspnea (1; AKT); Dysuria (f; DEP; KAB); Edema (1; APA; MPI); Endometriosis (f; KAP); Enterosis (f; KAB); Fever (f; MPI; WOI); Fracture (f; KAB); Fistula (f; KAB); Gas (f; DEP; KAB; KAP); Gastrosis (f; WOI); Gingivosis (f; WOI); Gleet (f; DEP); Hay Fever (f; WOI); Hemorrhoid (f; DEP; KAB); Hepatosis (f; MBB); High Blood Pressure (f; KAP); High Cholesterol (1; APA; KAP; PNC; SKY); High Triglyceride (1; APA; KEB; SKY); Hyperlipemia (1; KAP; KEB); Hysteria (f; DEP); Immunodepression (1; WOI); Impotence (f; DEP); Inflammation (1; APA; KAB; KAP; KEB; MBB;
PNC); Ischemia (1; KEB); Laryngosis (f; WOI); Lassitude (f; KAP); Leprosy (f; DEP; KAP); Leukoderma (f; KAB); Menorrhagia (f; KAP); Myosis (f; KAB); Neurosis (f; DEP; KAB; KAP); Obesity (1; KEB; MBB; MPI; PNC); Odontosis (f; SKJ); Otosis (f; KAB); Pain (1; AKT; JBU; KAP); Phthisis (f; WOI); Psoriasis (f; AKT); Pulmonosis (f; KAB); Pyorrhea (f; WOI); Rheumatism (1; DEP; KAB; SKJ); Sciatica (f; DEP); Scrofula (f; KAB); Scurvy (f; DEP); Rhinosis (f; WOI); Snakebite (f; KAB); Sore (1; DEP; KAB; SKJ); Sting (f; KAB); Stone (f; KAB); Swelling (1; APA; KEB; MPI); Syphilis (f; DEP); Thrombosis (1; KEB); Water Retention (f; WOI); Worm (f; KAB).

Dosages (Gugul) :
- 25 mg guggulsterones 2 - 3 ×/day (APA); 250 - 500 mg StX (5 - 10% guggulsterone) (APA; SKY); 1200 - 1500 mg guggulipid/day (ca 40 - 60 mg guggulsterone) (KEB);1.5 drachms (DEP).

Contraindications, Interactions, and Side Effects (Gugul) :
- Class 2b. Emmenagogue and uterotonic (AHP). Anorexia, apprehension, colic, dermatosis, diarrhea, eructations, headache, hiccup, nausea, and restlessness were documented side effects of crude oleoresin or guggulipid therapy (CAN; KEB; SKY). Persons with diarrhea, hepatosis, and IBS should be cautious (SKY). A practitioner should be consulted when treating high cholesterol or triglycerides (SKY). In view of the lack of toxicological data, excessive use, especially during lactation and pregnancy, should be avoided (CAN).

Extracts (Gugul) :
- Gugul resin lowers cholesterol and lipids in animals and humans. The oleoresin fraction was antiarthritic and antinflammtory in rats (MED = 125 mg/kg rat). Aqueous extracts are antiedemic (MPI). It inhibits platelet aggregation, causes inflammation in rats, activates the thyroid in chickens and rats, and increases catecholamine biosynthesis and activityin cholesterol-fed rabbits.