Dosages (Fenugreek) : - 1 tbsp mashed seed/8 oz water, up to 3 ×/day as gargle (APA); 1 - 6 g seed 3 ×/day (CAN); 5 - 90 g seed/day (SKY); 0.25 - 0.5 cup seed (PED); 6 - 12 g dry seed (PED); 50 g powdered seed with 0.25 liter water (HH2); 6.3 g/day (MAD); 1 (620 mg) capsule 2 - 3 ×/day (NH).
Contraindications, Interactions, and Side Effects (Fenugreek) : - Class 2b (AHP). Hazards and/or side effects not known for proper therapeutic dosages (PH2). Contraindicated in pregnancy (PH2). Due to its oxytoxic and uterine stimulant actions, in vitro, its use in pregnancy and lactation is to be avoided. Commission E reports no contraindications or interactions for oral use of the seed. Adverse skin reactions to repeated external use (AEH). An idiosyncratic gastroenterosis was fingered on fenugreek in LRNP (July 1987). One woman with micromazia complained of mastogenic activity following ingestion of fenugreek sprouts. May interfere with anticoagulant, blood sugar, hormonal, and/or MAOI therapies. High mucilaginous/fiber content may interfere with absorption of other drugs. Since all herbs, spices, and food plants, like drugs, contain pharmacologically active ingredients, it seems it could go without saying, the presence of pharmacologically active constituents would suggest that excessive ingestion is inadvisable (CAN). Alcoholic seed extract LD50 = 5000 mg/kg orl rat; 2000 der rabbit (CAN). Converted to niacin and other pyridines and pyrroles when cooked (PED).
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