CELANDINE CHELIDONIUM MAJUS

CELANDINE (Chelidonium majus L.) +

Activities (Celandine) :
- Abortifacient (f; MAD); Alterative (f; CRC; PNC); Analgesic (1; CRC; PH2; PNC); Anthelminthic (f; MAD); Antiaggregant (1; MAB); Antianaphylactic (1; PNC); Antibacterial (1; PNC); Anticancer (f; CRC); Antiherpetic (1; MAB); Antiinflammatory (1; MAB; PNC); Antileukotriene (1; MAB); Antimutagenic (1; MAB); Antisarcomic (1; MAB); Antiseptic (1; MAB; PH2); Antispasmodic (1; KOM; MAB; SHT); Antithromboxane (1; MAB); Antitussive (1; PNC); Antitumor (1; MAB); Antiviral (1; BRU; MAB); Aphrodisiac (f; CRC); Candidicide (1; HH2; MAB); Cholagogue (1; BRU; PH2; SHT); Cholekinetic (1; MAB; SHT); Choleretic (1; BRU; MAB; SHT); CNS-Depressant (1; HHB; PH2); Collyrium (f; CRC); Cytotoxic (1; KOM; MAB; PH2); Deobstruent (f; CRC); Diaphoretic (f; CRC; MAD); Diuretic (1; MAD; PNC); Expectorant (f; CRC); Fungicide (1; HH2; MAB); Hepatoprotective (1; CRC; MAB); Hepatotoxic (1; BRU); ypoglycemic (f; CRC); Hypotensive (1; KOM; PH2; PNC); Immunostimulant (1; KOM; PH2); Keratopreventive (1; MAB); Laxative (f; CRC); 5-Lipoxygenase-Inhibitor (1; MAB); 12-Lipoxygenase-Inhibitor (1; MAB); Myocontractant (f; PH2); Myorelaxant (1; PNC); Protisticide (1; MAB); Sedative (f; CRC; HHB); Trichomonicide (1; MAB); Uterocontractant (1; PH2); Vulnerary (1; MAB).

Indications (Celandine) :
- Adenopathy (f; JLH); Amenorrhea (f; FAD; MAD); Anaphylaxis (1; PNC); Angina (f; HHB; PHR); Anorexia (2; PHR); Arthrosis (f; MAD); Ascaris (f; CRC); Asthma (f; MAD; PHR; PH2); Atherosclerosis (f; HH2; PHR; PH2); Bacteria (1; BRU; PNC); Biliary Dyskinesia (2; KOM; SHT); Bleeding (f; MAD); Bronchosis (1; MAB; MAD; PNC); Bronchospasm (1; PNC); Callus (f; CRC); Cancer (1; CRC; MAB; PHR); Cancer, breast (1; CRC; JLH); Cancer, colon (1; CRC; FNF; JLH); Cancer, jaw (1; CRC; FNF; JLH); Cancer, kidney (1; CRC; JLH); Cancer, lip (f; CRC; JLH); Cancer, liver (f; CRC; FNF; JLH); Cancer,
lung (1; MAB); Cancer, mouth (1; CRC; FNF; JLH); Cancer, neck (1; CRC; FNF; JLH); Cancer, nose (1; CRC; FNF; JLH; PH2); Cancer, ovary (f; CRC; FNF; JLH); Cancer, parotid (1; CRC; FNF; JLH); Cancer, penis (1; CRC; FNF; JLH); Cancer, pharynx (1; FNF; PH2); Cancer, rectum (1; CRC; FNF; JLH); Cancer, skin (f; CRC; FNF; JLH); Cancer, spleen (1; CRC; FNF; JLH); Cancer, stomach (1; CRC; FNF; JLH; PH2); Cancer, testicle (1; CRC; FNF; JLH); Cancer, tongue (1; CRC; FNF; JLH); Cancer, urethra (1; CRC; FNF; JLH); Cancer, uterus (1; CRC; FNF; JLH); Candida (1; HH2; MAB); Catarrh (f; HHB; PHR); Cholangosis
(2; MAB); Cholecystosis (2; CRC; HHB; MAB; MAD; PHR; PH2); Cholelithiasis (2; MAB); Colitis (1; MAB); Colonic Polyposis (2; MAB); Condylomata (1; CRC; HH2; MAB); Corneal Opacity (f; MAB; MAD); Corn (f; CRC; PNC); Cramp (2; HHB; KOM; MAB; PH2; SHT); Dermatosis (f; PH2); Dysmenorrhea (1; PHR); Dyspepsia (f; MAB); Eczema (f; CRC; FAD); Edema (f; MAD; PHR; PH2); Egilops (f; CRC); Enterosis (2; HHB; KOM; MAB); Epithelioma (f; MAD); Escherichia (1; HH2); Exanthema (f; MAD); Fever (f; CRC; MAD); Fistula (f; MAD); Freckle (f; CRC; MAD); Frigidity (f; CRC); Fungus (1; HH2; MAB); Gallstone (f;
MAD); Gastrosis (2; BRU; HHB; KOM; MAB); Gastrospasm (2; KOM); Gonorrhea (f; MAD); Gout (f; CRC; MAD; PHR; PH2); Headache (f; MAB); Hematuria (f; MAD); Hemorrhoid (1; CRC; FAD); Hepatosis (2; CRC; MAB; MAD; PHR; PH2); Herpes (1; MAB); High Blood Pressure (1; KOM; PHR; PH2; PNC); Hyperglycemia (f; CRC); Hypertonia (f; KOM; PH2); Hypochondria (f; MAD); IBS (2; MAB); Immunodepression (1; KOM; PH2); Induration (f; CRC); Infection (1; HH2; MAB); Inflammation (1; FAD; MAB; PNC); Insomnia (f; CRC; HHB); Jaundice (f; CRC; HHB; MAB; MAD; PHR; PH2); Lupus (f; MAD); Malaria (f; MAD); Mastosis (f; JLH; PH2); Migraine (1; MAB); Myalgia (f; HHB); Mycosis (1; HH2; MAB);
Nervousness (f; CRC; HHB); Neuralgia (f; HHB); Ophthalmia (f; MAD); Pain (1; CRC; HHB; PH2; PNC); Parotosis (f; JLH); Pertussis (2; MAB; MAD; PNC); Pharyngosis (f; PH2); Phimosis (f; MAD); Phthisis (f; MAD); Pneumonia (f; HHB; MAD); Polyp (2; CRC; MAB; PHR; PH2); Psoriasis (1; CRC; MAB; MAD); Rash (f; PH2); Respirosis (f; MAD); Rheumatism (f; HHB); Rhinosis (f; JLH; PH2); Ringworm (f; CRC; FAD); Scabies (f; MAD; PHR; PH2); Scurvy (f; CRC); Scrofula (f; CRC); Sore (f; MAD); Shigella (1; HH2); Splenosis (f; MAD); Staphylococcus (1; HH2; MAD); Stomachache (f; HHB); Stone (f; HHB; MAD; PHR);
Tenesmus (f; MAD); Toothache (f; MAD; PHR); Tuberculosis (f; MAD); Tumor (1; CRC; MAB); Ulcer (f; CRC); Vaginosis (1; MAB); Vertigo (f; MAD); Virus (1; BRU; MAB); Wart (f; CRC; HHB; MAB; MAD; PHR); Water retention (1; MAD; PNC); Wen (f; CRC); Wound (f; CRC; FAD); Yeast (1; HH2; MAB). Spastic discomfort of the bile ducts and gastrointestinal tract (KOM).

Dosages (Celandine) :
- 0.5 g herb single dose (HHB); 3 - 9 g herb/day (MAB); 2 - 5 g crude herb (or 12 - 30 mg total alkaloids) (KOM; SHT); 0.5 g root (PHR); 2 - 4 ml liquid extract PNC); 1 - 2 ml/day fluid extract (1:2) (MAB); 2 - 4 ml/day tincture (1:5) (MAB); 1.8 - 7.5 g juice (MAD).

Contraindications, Interactions, and Side Effects (Celandine) :
-  Class 2b, 2d (AHP). None known (KOM). Not to be used by children (AHP). Canadian regulations do not allow celandine in food. Australians counsel that it may affect glaucoma treatment. Germans report that it takes more than 500 g celandine to cause toxic effects in cattle and horses (AHP). Side effects
include dry mouth and dizziness (PNC). Overdoses can cause dizziness, hematuria, intestinal colic, stomach pain, and urinary urgency (SHT). Consumption of fresh herb may cause GI distress (AHP). Stem juice allergenic, irritant, and paralytic (FAD). Thought to be hepatotoxic (BRU).

Extracts (Celandine) :
- Extracts, as well as chelidonine, chelerythrine, protopine, and sanguinarine have antibacterial and antitussive activities (PNC). Chelidonine lowers arterial blood pressure, relaxes smooth muscle spasms and bronchial spasm, increases urine production, and delays or inhibits the development of anaphylactic shock in vivo. Alpha-allocryptopine, chelidonine, and sanguinarine have in vivo analgesic activities (PNC). LD50 (decoction) 9500 mg/kg ipr mouse (MAB); LD50 (alkaloids) 300 mg/kg scu mouse (MAB).