Dosages (Bugleweed) : - Take only under doctors supervision (APA); 1 - 2 drachms dried herb (FEL); 2 drachms to 4 fluid oz strong tincture (FEL); 1 - 2 g dry herb/tea (PH2); 0.7 - 2 ml liquid herb extract (PNC); 0.2 - 2 g/day crude drug (SHT).
Contraindications, Interactions, and Side Effects (Bugleweed) : - Class 2b, 2c, 2d. Contraindicated in thyroid enlargement or hypothyroid, and in simultaneous administration of other thyroid treatments (AHP). Long-term use can cause thyroid enlargement. Hazards and/or side effects not known for proper therapeutic dosages (PH2). Avoid sudden withdrawal; may increase prolactin secretion (SHT).
Extracts (Bugleweed) : - Extracts have demonstrated antigonadotropic, antithyrotropic, and prolactin-lowering activities (SHT). Freeze-dried extract induces pituitary thyroid stimulating hormone (TSH) repletion in hypothyroid rats, and reduction of TSH levels in euthyroid rats. Extracts also prevent bovine TSH binding to and stimulating adenyl cyclase in human thyroid membranes. Extracts used empirically in the treatment of Graves disease, in which a thyroid-stimulating antibody is found in the blood; this antibody has been shown to bind to and be inhibited by the plant extract (PNC).
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