Contraindications, Interactions, and Side Effects (Blue Cohosh): - Class 2b (AHP). Hazards and/or side effects not known for proper therapeutic dosages (PH2). CAN caution that the poisonous seeds will irritate the GI tract. Because it is reputed to be abortifacient and to affect the menstrual cycle, its use in pregnancy and lactation is to be avoided. May interfere with angina therapy (CAN). Anagyrines may be teratogenic (PHR). Canadian regulations do not allow blue cohosh as a nonmedicinal ingredient for oral use products (Michols, 1995). The alcoholic extract was uterotonic in guinea pig; caulosaponin is oxytocic to rat uterus in vivo; even low-potency homeopathic produce follicular and endometrial changes likened to inhibition of ovulation; administration of this homeopathic preparation interrupted implantation (De Smet et al., 1993).
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