Dosages (Baical Skullcap): 3 - 10 g/day (AKT); 3 - 9 g root/day (FAY); 2 - 6 g dry root/day or 4 - 12 ml fluid extract (1:2) (KEB).
Contraindications, Interactions, and Side Effects (Baical Skullcap): Class 1 (AHP). Rating 4 (APA). Not indexed by Commission E (KOM); may be additive with other anticoagulants, like warfarin.
Extracts (Baical Skullcap): Decoction LD50 >10,000 mg/kg orl rabbit; LD50 baicalin 3081 mg/kg ivn mouse. Decoction sedative at 10,000 mg/kg orally in rabbits; tincture sedative at 2000 mg/kg intravenously in rabbits (LAF). My only quantified sources of the COX-2 inhibitor, baicalein (COX).
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