Dosages (Agrimony): - 3 g herb (KOM; PHR); 3 - 6 g herb (APA); 1 - 1.5 g (BIS); 2 - 4 g 3 ×/day (CAN); 1 tsp herb/cup water (RFW); 1 - 3 ml extract (1:1 in 25% ethanol) 3 ×/day (CAN); 2 - 4 ml liquid herb extract (PNC); 1 - 4 ml tincture (1:5) in 45% alcohol 3 ×/day (CAN).
Contraindications, Interactions, and Side Effects (Agrimony): - Class 1 (AHP). None known (Kom; PHR). Hazards and/or side effects not known for proper therapeutic dosages (PH2). Excessive doses may interact with anticoagulant, hypotensive, and hypertensive therapies. As with other tannin-rich herbs, excessive use should be avoided. In view of the lack of toxicity data, use of agrimony should be avoided during pregnancy and lactation. Reportedly affects the menstrual cycle (CAN).
Extracts (Agrimony): - Uricolytic activity demonstrated for 15% infusions ED = 20 ml/kg orl rat (equivalent to 3 g dry drug); hypotensive (ivn cat); bactericidal against Staphylococcus and Streptococcus. The tannin constituent agrimoniin (from A. pilosa) has antitumor activity, perhaps via immunostimulant activity (CAN). Aqueous extracts inhibited Mycobacterium tuberculosis, in vitro, and ethanolic extracts show antiviral activity (PNC). Twenty cutaneous porphyria patients successfully treated with agrimony infusions. Chinese research indicates agrimony increases blood coagulability ~50% (CAN).
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