IMPOTENCE TREATMENT
Category: Urology
Abstract :
Impotence treatment Psychosexual therapy : Aims to understand and address
underlying psychological issues, and provides information and treatment in the
form of sex education, instruction on improving partner communication skills,
cognitive therapy, and behavioural therapy (programmed re-learning of couple's
sexual relationship). Oral medication : - Phosphodiesterase type-
Impotence treatment Psychosexual therapy : Aims to understand and address
underlying psychological issues, and provides information and treatment in the
form of sex education, instruction on improving partner communication skills,
cognitive therapy, and behavioural therapy (programmed re-learning of couple's
sexual relationship).
Oral medication : - Phosphodiesterase type-5
(PDE5) inhibitors: sildenafil (Viagra); tadalafil (Cialis); vardenafil
(Levitra). PDE5 inhibitors enhance cavernosal smooth muscle relaxation and
erection by blocking the breakdown of cGMP. Sexual stimulus is still required to
initiate events. Side-effects: headache; flushing; visual disturbance.
Contraindications: patients taking nitrates; recent myocardial infarction;
recent stroke; hypotension; unstable angina.
- Dopamine receptor agonist:
apomorphine (Uprima). Apomorphine is administered sublingually, and acts
centrally on dopaminergic receptors in the paraventricular nucleus of the
hypothalamus to enhance and co-ordinate the effect of sexual stimuli. Adverse
effects: nausea; headache; dizziness.
Androgen replacement
therapy testosterone replacement is indicated for hypogonadism. It is
available in oral, intramuscular, pellet, patch, and gel forms. In older men, it
is recommended that PSA is checked before and during
treatment.
Intraurethral therapy alprostadil (MUSE). Synthetic
prostaglandin E1 (PGE1) pellet administered into the urethra via a specialized
applicator. Once inserted, the penis is gently rolled to encourage the pellet to
dissolve into the urethral mucosa, from where it enters the corpora.
Side-effects: penile pain; priapism; local reactions.
Intracavernosal
therapy alprostadil/Caverjet (synthetic PGE1); papaverine (smooth muscle
relaxant) ± phentolamine (α-adrenoceptor agonist). Training of technique and
first dose is given by health professional. Needle is inserted at right angles
into the corpus cavernosum on the lateral aspects of mid-penile shaft. Adverse
effects: pain; priapism; haematoma.
Vacuum erection device it contains
3 components: vacuum chamber, pump, and constriction band. The penis is placed
in the chamber and the vacuum created by the pump increases blood flow to the
corpora cavernosa to induce an erection. The constriction band is placed onto
the base of the penis to retain blood in the corpora and maintain rigidity.
Adverse effects: penile coldness; bruising.
Penile
prosthesis semi-rigid, malleable, and inflatable penile prostheses are
available for surgical implantation into the corpora to provide penile rigidity
and sufficient erectile size for sexual intercourse. Side-effects: mechanical
failure; erosions; infections.
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